Publication
Over 40 journal publications, including 10 in Nature Biomedical Engineering, Nature Photonics, Nature Methods, Nature Protocols, Science Robotics, Nature Communications, and Science Advances. Google Scholar: Total citation >2400, h-index, 23
(*co-first author)
Selected Publications
2021
L. Li, Y. Li, Y. Zhang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo,' Nature Protocols 16, 2381–2394
Featured by Nature Protocols in April, 2021
2020
Y. Li*, L. Li*, L. Zhu*, K. Maslov, J. Shi, P. Hu, E. Bo, J. Yao, J. Liang, L. Wang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption,' Nature Photonics 14, 164–170
Highlighted in “Photoacoustics in a snap', Editor's Research Highlight, Nature Methods, 2020, 17, 248.
Highlighted in Caltech News, Photonics Views, Machine Design, Phys.org.
2019
J. Yang*, L. Li*, A. A. Shemetov*, S. Lee, Y. Zhao, Y. Liu, Y. Shen, J. Li, Y. Oka, V. V. Verkhusha, L. V. Wang. “Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star,' Science Advances 5 (12), eaay1211, 1–9
Z. Wu*, L. Li*, Y. Yang, P. Hu, Y. Li, S. Yang, L. V. Wang, W. Gao (2019). “A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo,' Science Robotics 4 (32): eaax0613, 1–11
Shi, J., T. T. Wong, Y, He, L. Li, R. Zhang, C. Yung, J. Hwang, K. Maslov, L. V. Wang. “High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy,' Nature Photonics 13(9), 609–615
Highlighted in Caltech News, Optics & Photonics News, Phys.org, Optics.org.
2018
L. Li, A. A. Shemetov, M. Baloban, P. Hu, L. Zhu, D. M. Shcherbakova, R. Zhang, J. Shi, J. Yao, L. V Wang, V. V. Verkhusha. “Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo,' Nature Communications 9 (1), 2734, 1–14
Indexed by Nature Index
L. Lin, P. Hu, J. Shi, C. Appleton, K. Maslov, L. Li, R. Zhang, L. V. Wang. “Single-Breath-Hold Photoacoustic Computed Tomography of the Breast,' Nature Communications 9 (1), 2352, 1–9
Highlighted in NIH Director’s Blog, featured by “5 Cool Technologies Your Tax Dollars are Funding'.
Highlighted in Caltech News, Electronics Weekly, physicsworld.com, Optics.org, Newswise, Health Data Management, Biomedical Picture of the Day.
2017
L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, L. V. Wang. “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,' Nature Biomedical Engineering 1, 0071, 1–11
Highlighted in “Photoacoustic tomography: Breathtaking whole-body imaging', Nature Biomedical Engineering, 2017, 1, 75.
Highlighted in “Laser pulses drum up sharp images of organs in motion' by NIH/NIBIB.
Selected as a top 10 article for the first anniversary of Nature Biomedical Engineering.
Top 10 most cited research article in Nature Biomedical Engineering.
Highlighted in Caltech News, Health Imaging, The Medical News, Photonics Media, Futurity, Seeker, ScienceDaily, Phys.org, EurekAlert.
2016
J. Yao*, A. A. Kaberniuk*, L. Li*, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, L. V. Wang. “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,' Nature Methods 13, 67–73
Highlighted in Medical News Today, Newswise, ecancer, Nanowerk, EurekAlert.
2015
J. Yao, L. Wang, J. M. Yang, K. Maslov, T. Wong, L. Li, C. H. Huang, J. Zou, L. V. Wang. “High-speed label-free functional photoacoustic microscopy of mouse brain in action,' Nature Methods 12, 407–410
Highlighted in “A faster way to watch blood flow in the brain', Science, aab0393
Highlighted in Phys.org, BioOptics World, Nanowerk, Today Topics, Medical News Today, Neuroscience, Newswise.
Peer Reviewed Journal Articles
2021
L. Li, H. Hsu, V. V. Verkhusha, L. V. Wang, D. M. Shcherbakova, “Multiscale photoacoustic tomography of a genetically encoded near-infrared FRET biosensor,” Advanced Science e2102474.
D. Lee, C. Qian, H. Wang, L. Li, K. Miao, J. Du, D. M. Shcherbakova, V. V. Verkhusha, L. V. Wang, L. Wei, "Toward photoswitchable electronic pre-resonance stimulated Raman probes", The Journal of Chemical Physics 154, 135102
M. Ochocinska, S. Spitalnik, A. Abuhamad, E. Bennett-Guerrero, W. Carlo, M. Cherukuri, A. Doctor, W. Dzik, C. Evans, E. Forzani, P. Kuppusamy, N. Moan, L. Li, N. Luban, N. Mohandas, R. Patel, J. Roback, H. Swartz, S. Textor, Sergei. Vinogradov, L. V. Wang, N. Wisniewski, S. Glynn. “NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion,” Transfusion Medicine Reviews 35(1):46-55. doi: 10.1016/j.tmrv.2020.12.003.
L. Li, Y. Li, Y. Zhang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo,” Nature Protocols 16, 2381–2394
L. Li, D. Patil, G. Petruncio, K. Harnden, J. Somasekharan, M. Paige, L. V. Wang, C. S. Morales. “Integration of multitargeted polymer-based contrast agents with photoacoustic computed tomography: An imaging technique to visualize breast cancer intratumor heterogeneity,” ACS Nano 15(2): 2413–2427
2020
P. Hu, L. Li, L. Lin, L. V. Wang. “Spatiotemporal antialiasing in photoacoustic computed tomography,” IEEE Transactions on Medical Imaging 39(11): 3535-3547
Y. Li, L. Li, L. Zhu, J. Shi, K. Maslov, L. V. Wang. “Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo,” Journal of Biomedical Optics 25(7): 070501, 1–8
Y. Li*, L. Li*, L. Zhu*, K. Maslov, J. Shi, P. Hu, E. Bo, J. Yao, J. Liang, L. Wang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption,” Nature Photonics 14, 164–170
J. Yang, L. Li, J. Li, Z. Cheng, Y. Liu, L. V. Wang. “Fighting against fast speckle decorrelation for light focusing inside live tissue by photon frequency shifting,” ACS Photonics 7(3): 837–844
2019
J. Yang*, L. Li*, A. A. Shemetov, S. Lee, Y. Zhao, Y. Liu, Y. Shen, J. Li, Y. Oka, V. V. Verkhusha, L. V. Wang. “Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star,' Science Advances 5 (12), eaay1211
Z. Wu*, L. Li*, Y. Yang, P. Hu, Y. Li, S. Yang, L. V. Wang and W. Gao. "A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo," Science Robotics 4 (32): eaax0613
Shi, J., T. T. Wong, Y, He, L. Li, R. Zhang, C. Yung, J. Hwang, K. Maslov, L. V. Wang. “High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy,' Nature Photonics 13(9), 609-615
P. Zhang*, L. Li*, L. Lin, J. Shi, L. V. Wang. “In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets,” Light: Science & Applications 8(36), 1–9
2018
L. Li, A. A. Shemetov, M. Baloban, P. Hu, L. Zhu, D. M. Shcherbakova, R. Zhang, J. Shi, J. Yao, L. V Wang, V. V. Verkhusha. “Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo,' Nature Communications 9 (1), 2734 (Indexed by Nature Index)
HC. Hsu, L. Li, J. Yao, T.W. Wong, J. Shi, R. Chen, Q. Zhou, L. V. Wang. “Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy,' Journal of Biomedical Optics 23 (7), 076001
L. Lin, P. Hu, J. Shi, C. Appleton, K. Maslov, L. Li, R. Zhang, L. V. Wang. “Single-Breath-Hold Photoacoustic Computed Tomography of the Breast,' Nature Communications 9 (1), 2352
T. P. Matthews, J. Poudel, L. Li, L. V. Wang, M. A. Anastasio. “Parameterized Joint Reconstruction of the Initial Pressure and Sound Speed Distributions for Photoacoustic Computed Tomography,' SIAM journal on imaging sciences 11 (2), 1560-1588
Y. Qu*, L. Li*, Y. Shen, X. Wei, T. W. Wong, P. Hu, J. Yao, K. Maslov, and L. V. Wang. “Dichroism-sensitive photoacoustic computed tomography,' Optica 5, 495-501
T. Imai, J. Shi, T. TW Wong, L. Li, L. V. Wang. “High-throughput ultraviolet photoacoustic microscopy with multifocal excitation,' Journal of Biomedical Optics 23(3), 036007
P. Zhang*, L. Li*, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, L. V. Wang. “High–resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,' Journal of Biophotonics 11(2), e201700196-n/a
W. Liu, Y. Zhou, M. Wang, L. Li, E. Vienneau, R. Chen, J. Luo, C. Xu, Q. Zhou, L. V. Wang, J. Yao. “Correcting the limited view in optical-resolution photoacoustic microscopy,' Journal of Biophotonics 11(2), e201700024-n/a
2017
L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, L. V. Wang. “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,' Nature Biomedical Engineering 1, 0071 (Highlighted as cover articles in Nature Biomedical Engineering in issue 5, 2017, selected as a top 10 article for the first anniversary, top 10 most cited research article in Nature Biomedical Engineering)
L. Li, L. Zhu, Y. Shen, L. V. Wang. “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,' Journal of Biomedical Optics 22 (7), 076017
J. Poudel, T. P. Matthews, L. Li, M. A. Anastasio, L. V. Wang, “Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method,' Journal of Biomedical Optics 22 (4), 041018-041018
T. Wong, Y. Zhou, A. Garcia-Uribe, L. Li, K. Maslov, L. Lin, L. V. Wang. “Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo,” Journal of Biomedical Optics 22(4), 041003, 1–6
L. Lin, P. Zhang, S. Xu, J. Shi, L. Li, J. Yao, L. Wang, J. Zou, L. V. Wang. “Handheld optical-resolution photoacoustic microscopy,' Journal of Biomedical Optics 22(4), 041002
C. Yeh*, L. Li*, L. Zhu, J. Xia, C. Li, W. Chen, A. Garcia-Uribe, K. Maslov, L. V. Wang. “Dry coupling for whole-body small-animal photoacoustic computed tomography,' Journal of Biomedical Optics 22 (4), 041003-041003
B. Rao, R. Zhang, L. Li, J. Shao, L. V. Wang. “Photoacoustic imaging of voltage responses beyond the optical diffusion limit,' Scientific Reports 7, 2560
2016
L. Li, J. Xia, A. Garcia-Uribe, Q. Sheng, M. Anastasio, and L. V. Wang. “Label-free photoacoustic tomography of whole mouse brain structures ex vivo,' Neurophotonics 3(3), 035001
J. Yao*, A. A. Kaberniuk*, L. Li*, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang. “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,' Nature Methods 13, 67–73
L. Lin, J. Yao, L. Li, L. V. Wang. “In vivo photoacoustic tomography of myoglobin oxygen saturation,' Journal of Biomedical Optics 21(6), 061002.
Y. He, L. Wang, J. Shi, J. Yao, L. Li, R. Zhang, C. Huang, J. Zou, L. V. Wang, “In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells,' Scientific Reports 6, 39616
2015
J. Yao, L. Wang, J. M. Yang, K. Maslov, T. Wong, L. Li, C. H. Huang, J. Zou, L. V. Wang. “High-speed Label-free Functional Photoacoustic Microscopy of Mouse Brain in Action,' Nature Methods 12, 407–410
G. Li, L. Li, L. Zhu, J. Xia, L. V. Wang. “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,' Journal of Biomedical Optics 20 (6), 066010
L. Lin, J. Xia, T. Wong, L. Li, L. V. Wang, “In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography,' Journal of Biomedical Optics 20 (1), 016019
2014
L. Zhu*, L. Li*, L. Gao, L. V. Wang. “Multi-view optical resolution photoacoustic microscopy,' Optica 1(4), 217-222
L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, K. Maslov, L. V. Wang (2014). “Fully motorized optical-resolution photoacoustic microscopy,' Optics Letters 39 (7), 2117-2120 (Highlighted as cover article in Optics Letters in issue 7, 2014; selected for re-exposure by Virtual Journal for Biomedical Optics)
Y. S. Zhang, J. Yao, C. Zhang, L. Li, L. V. Wang, Y. Xia. “Optical-resolution photoacoustic microscopy for volumetric and spectral analysis of histological and immunochemical samples,' Angewandte Chemie International Edition. doi: 10.1002/anie.201403812
2013 and before
J. Cui, L. Li, J. Tan (2013). “Sensing technology and method based on double fiber coupling of return energy for micro-hole measurement,' Sensors and Actuators A: Physical 190, 13-18
J. Cui, L. Li, J. Tan (2012). “Opto-tactile probe for inner dimension measurement with high aspect ratio,' Measurement Science and Technology 23 (8), 085105
J. Cui, L. Li, J. Tan (2011). “Optical fiber probe based on spherical coupling of light energy for inner-dimension measurement of microstructures with high aspect ratio,' Optics Letters 36 (23), 4689-4691
Book Chapters and Review Articles
L. Li, J. Yao, L. V. Wang (2019). “Photoacoustic tomography of neural system,' in Neural Engineering (In press)
L. Li, L. Lin, L. V. Wang (2018). “Multiscale photoacoustic tomography,' in Optics and Photonics News 29(4) 32-39 (Invited review article)
M. Zhou*, L. Li*, J. Yao, R. R. Bouchard, L. V. Wang, C. Li (2017). “Nanoparticles for Photoacoustic Imaging of Vasculature,' in Design and Applications of Nanoparticles in Biomedical Imaging, 337–356
L. Li, J. Yao, L. V. Wang (2016). “Photoacoustic Tomography Enhanced by Nanoparticles,' in Wiley Encyclopedia of Electrical and Electronics Engineering, J. G. Webster (Ed.). doi:10.1002/047134608X.W8335
Conference Proceedings
L. Li, A. A. Shemetov, P. Hu, D. M. Shcherbakova, J. Shi, J. Yao, V. V. Verkhusha, L. V. Wang (2019). “In vivo photoacoustic multi-contrast imaging and detection of protein interactions using a small near-infrared photochromic protein,' SPIE BiOS, 1087818-6
L. Li, P. Zhang, L. V. Wang (2018). “Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo,' SPIE BiOS, 104941H-6
L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, L. V. Wang, (2017). “Imaging small animal whole-body dynamics by single-impulse panoramic photoacoustic computed tomography,' SPIE BiOS, 100640M-6
J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, 6 / 7 (2016). “Reversibly switchable photoacoustic tomography using a genetically encoded near-infrared phytochrome,' SPIE BiOS, 97082U-8
T. P. Matthews, L. Li, L. V. Wanga, M. Anastasia (2016). “Compensation for air voids in photoacoustic computed tomography image reconstruction,' SPIE BiOS, 970841-6
G. Li, J. Xia, L. Li, L. Wang, L. V. Wang (2015), “Isotropic-resolution linear-array-based photoacoustic computed tomography through inverse Radon transform,' SPIE BiOS, 93230I-7
C. Yeh, S. Hu, J. Liang, L. Li, B. Soetikno, Z. Lu, R. Sohn, K. Maslov, J. M. Arbeit, L. V. Wang (2015). “Opticalresolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model,' SPIE BiOS, 93233H-8
L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, K. Maslov, R. Chen, Q. Zhou, K. K. Shung, L. V. Wang (2014). “Fully motorized optical-resolution photoacoustic microscopy,' BIOMED, BS3A.69
L. Zhu, L. Gao, L. Li, L Wang, T Ma, Q Zhou, K. K. Shung, L. V. Wang (2014). “Cross-optical-beam nonlinear photoacoustic microscopy,' SPIE BiOS, 89433H-5
L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, K. Maslov, L. V. Wang (2014). “Combined optical and mechanical scanning in optical-resolution photoacoustic microscopy,' SPIE BiOS, 89435X-6
J. Cui, L. Li, J. Tan (2010). “Development of ultra-precision micro-cavity measurement technique in HIT-UOI,' Proc. SPIE 7544, 75441A; doi:10.1117/12.885701